Results
| PMID | 24807378 |
| Gene Name | NPY |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 198 |
| Sex | Female |
| Associated genes | S100, NSE, SP, VIP, NPY, NKA, NKB, NKR1, NKR2, and NKR3 |
| Other associated phenotypes |
Endometriosis |
|
Reprod Sci. 2015 Jan;22(1):124-31. doi: 10.1177/1933719114534536. Epub 2014 May Di Spiezio Sardo, Attilio| Florio, Pasquale| Fernandez, Loredana Maria Sosa| Guerra, Germano| Spinelli, Marialuigia| Di Carlo, Costantino| Filippeschi, Marco| Nappi, Carmine Department of Gynecology and Obstetrics and Pathophysiology of Human Reproduction, University of Naples "Federico II," Naples, Italy.| U.O.C. Obstetrics & Gynecology, "S. Giuseppe" Hospital, Empoli, Italy floriop@hotmail.com.| Department of Gynecology We aimed to evaluate whether nerve fibers are present in the endometrial layer of patients submitted to office hysteroscopy and their potential contribution to the pathogenesis of pain during that procedure. Through a prospective case-control study performed in tertiary centers for women's health, endometrium samples were collected during operative office hysteroscopy from 198 cycling women who previously underwent laparoscopy and/or magnetic resonance imaging investigation for infertility assessment. Samples were classified according to the degree of the pain patients experienced and scored from values ranging from 0 (absence of discomfort/pain) to 10 (intolerable pain) on a 10-cm visual analog scale (VAS). The presence of nerve fiber markers (S100, NSE, SP, VIP, NPY, NKA, NKB, NKR1, NKR2, and NKR3) in the endometrium was also evaluated by morphologic and immunohistochemical analyses. We found that S-100, NSE, NKR1, NK-A, NK-B, VIP, and NPY, were immunolocalized in samples of endometrium, in significantly (P < .01, for all) higher levels in samples collected from patients with VAS score > 5 (group A) than Mesh Terms: Adenomyosis/*pathology/physiopathology| Adult| *Ambulatory Care| Biopsy/*adverse effects| Case-Control Studies| Endometriosis/*pathology/physiopathology| Endometrium/*innervation/pathology/surgery| Female| Humans| Hysteroscopy/*adverse effects| |
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